College of Natural Science, University of Texas, USA, said on the 21st that through in-depth analysis of the relationship between yeasts, frogs, laboratory mice, and human evolution, researchers at the hospital discovered a cheap anti-fungal drug, which may slow tumor growth. Helps find new ways of cancer chemotherapy.
Pybilin has been used in clinical medicine for 40 years as an oral antifungal drug, but it has never been used for cancer treatment. Scientists at the University of Texas, Cha Haiji, Edward Markut, and John Wallingford, and colleagues found that Pyrenein is like a blood vessel breaking agent that can destroy new blood vessels. Related research was published in the journal Science Public Libraries and Biology.
Tumors usually induce the formation of new blood vessels to provide nutrition for their uncontrolled growth. Inhibiting blood vessel growth is a very important chemotherapy because it can "starve" the tumor. In experiments with experimental mice, scientists found that Pyreneol can reduce the growth of blood vessels in fibrosarcoma by more than half. At the same time, Pyreneol can also slow the growth of tumors.
Chemistry professor Markot said that the new findings are encouraging because they have for the first time discovered that the drugs that have been approved for use have the effect of breaking human blood vessels. Studies have shown that Pybilene may be combined with other chemotherapy regimens for the clinical treatment of cancer. This new discovery is a model of interdisciplinary and cross-biological research.
In studies completed in the past, Markot and colleagues discovered that genes shared by unicellular yeasts and vertebrates share evolutionary history. In blood vessels-free yeast, the shared genes are responsible for responding to the different pressures exerted on the cells; in vertebrates, the shared genes are repurposed to manage the growth of arteries and veins or angiogenesis.
Markut and colleagues conclude that by analyzing this particular set of genes, it is possible to verify that drugs that act on yeast can also be used as angiogenesis inhibitors for cancer chemotherapy. The final experimental results prove that their inferences are correct.
The task of Cha Haiji, a graduate student in the Department of Cellular and Molecular Biology, is to find molecules that can inhibit gene activity in yeast and found that Pyreneol has the required functions. Subsequently, she conducted drug experiments on frog embryos during development. She found that when frog embryos were grown in water containing chlorpheniridine, either they did not grow blood vessels or the blood vessels that grew quickly were dissolved by the drug. After removing the drug, the blood vessels of the frog's embryos grow. Next, Chahaghi conducted a drug experiment on human vascular cells in a petri dish and found that the drug can also inhibit the growth of vascular cells. Finally, she applied the drug to experimental mice with fibroid tumors. The result was that the drug slowed blood vessel growth and slowed the growth of the tumor. (Reporter Mao Li)
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